Evaluation of propofol and ketamine anaesthesia in butorphanol-diazepam premedicated geriatric dogs

Arora, Akshi (2017) Evaluation of propofol and ketamine anaesthesia in butorphanol-diazepam premedicated geriatric dogs. Masters thesis, Sher-E-Kashmir University of Agricultural Sciences and Technology of Jammu.

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The study was conducted to evaluate and compare the induction and maintenance of anaesthesia with ketamine and propofol in glycopyrrolate-butorphanol-diazepam premedicated geriatric dogs undergoing various surgeries. The animals premedicated with glycopyrrolate, butorphanol and diazepam were randomly divided into two groups, K and P, of six animals each. Anaesthesia was induced by intravenous administration of ketamine and propofol in Groups K and P, respectively. The pedal, palpebral, corneal and swallowing reflexes were only mildly depressed, muscle rigidity was present and the animals did not attain surgical plane of anaesthesia, thus no surgical procedure could be conducted in any of the animals of group K. However, in Group P, all these reflexes abolished completely, induction was rapid and smooth; surgical plane of anaesthesia was attained and prolonged by administering incremental doses of propofol. The quality of recovery in group K was poor, whereas it was good (rapid, smooth and gained consciousness without struggling or vocalization) in group P. The haemato-biochemical alterations in both the groups were not significant (p>0.05) and all the parameters viz. Hb, PCV, TLC, DLC, total protein, albumin, Albumin: Globulin, ALT, AST, BUN and creatinine parameters, recorded at various time intervals, remained within normal range close to the base values in both the groups. Rectal temperature decreased significantly in group P (p<0.05). Heart rate increased markedly in both the groups, however increase was significant (p<0.05) in group K. There was a non significant increase in mean arterial pressure at 15 and 30 minutes after the administration of ketamine in group K, whereas a non significant decrease in MAP was observed in group P. Alterations in ECG pattern were not significant except sinus tachycardia at all intervals and occasional ventricular premature complexes in both groups at T15 interval.

Item Type: Thesis (Masters)
Additional Information: Registration No. : J-15-MV-424
Uncontrolled Keywords: Anaesthesia, Dogs, Geriatric, Butorphanol, Glycopyrrolate, Diazepam, Ketamine, Propofol
Subjects: S Agriculture > Veterinary Surgery and Radiology
Divisions: Department of Agriculture
Date Deposited: 31 May 2018 06:00
Last Modified: 31 May 2018 06:00

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